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Novel Antibodies for the Characterization of CAR-T Cells (31:47)

Learn how CAR linker antibodies can interrogate the expression of an... entire panel of CARs, fastser and easier than ever.

Analytical Tools to Evaluate CAR T-Cell Signaling & Activation (45:23)

Generation and Validation of Anti-Linker Monoclonal Antibodies for the Surface Detection of scFv-based CARs (5:25)

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一种用于检测、富集和激活表达 scFv 嵌合抗原受体细胞的新型单克隆抗体

In this poster, we report on a novel and highly versatile recombinant rabbit monoclonal antibody raised against the Gly₄Ser peptide linker, which is commonly integrated into single-chain variable fragment (scFv)-based CARs. This antibody can be leveraged for flow cytometry-based CAR detection, magnetic bead-based CAR-T cell enrichment, and selective activation of CAR transduced cells.

Generation and validation of anti-linker monoclonal antibodies for the surface detection of scFv-based CARs

这张在 AACR 年会上展示的海报描述了兔单克隆抗体的生成和验证，该抗体针对通常整合到针对 CAR-T 疗法开发的基于单链可变片段 (scFv) 的嵌合抗原受体 (CAR) 中的两个接头蛋白序列。